The Princess Margaret (PM) RNA Medicine Core is a non-profit academic center dedicated to offering cost-effective, high-quality RNA medicine services. Our advanced facilities and expert team collaborate with academic and industry partners to develop and test new RNA-based therapies. We specialize in mRNA, ionizable lipid, siRNA-LNP, mRNA-LNP, and ASO-LNP synthesis.

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We support RNA-LNPs preparation for dry run tests (i.e., 2 µg of mRNA/custom RNAs or 3 nmol of siRNA/ASO), in vitro scale (>= 50 µg of mRNA/custom RNAs and >= 10 nmol of siRNA/ASO), and in vivo scale (> 500 µg of mRNA and > 250 nmol of siRNA/ASO). Our quality control (QC) processes ensure the integrity, purity, and functionality of RNA samples, as well as the particle size, particle uniformity, and encapsulation efficiency of RNA-LNPs in various preparation scales.
 

Visit our website to learn more about our services, team, and facilities. Whether you’re interested in RNA molecule design, in vitro and in vivo studies, or developing RNA-based therapies, we have the expertise and resources to support your research goals. If you need a service not listed, please inquire!