Publications

Our publications cover a wide range of topics, from RNA structure and function to the development and testing of new RNA-based therapies.

Featured

Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry

Nature Materials, 2024

https://www.nature.com/articles/s41563-024-01867-3

Bowen Li, Idris O. Raji, Akiva G. R. Gordon, Lizhuang Sun, Theresa M. Raimondo, Favour A. Oladimeji, Allen Y. Jiang, Andrew Varley, Robert S. Langer & Daniel G. Anderson

Tumor-Tailored Ionizable Lipid Nanoparticles Facilitate IL-12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy

Advanced Materials, 2024

https://doi.org/10.1002/adma.202400307

Shufen Xu, Yue Xu, Nicholas C. Solek, Jingan Chen, Fanglin Gong, Andrew James Varley, Alex Golubovic, Anni Pan, Songtao Dong, Gang Zheng, Bowen Li

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA

Nature Biomedical Engineering, 2023

https://www.nature.com/articles/s41551-023-01082-6

Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M. Raimondo, Akiva G. R. Gordon, Luke H. Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, Haseeb Mughal, Taras M. Chicz, Yue Xu, Ryan P. McNamara, Sangeeta Bhatia, Galit Alter, Robert Langer & Daniel G. Anderson

Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects

PNAS, 2023

https://doi.org/10.1073/pnas.2309472120

Jingan Chen, Yue Xu, Muye Zhou and Bowen Li

Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles

ACS Nano, 2023

https://doi.org/10.1021/acsnano.2c10936

Yulin Mo, Miffy HY Cheng, Andrew D’Elia, Katie Doran, Lili Ding, Juan Chen, Pieter R Cullis, Gang Zheng

Rational design and combinatorial chemistry of ionizable lipids for RNA delivery

J. Mater. Chem. B, 2023

https://doi.org/10.1039/D3TB00649B

Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, and Bowen Li

AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery

bioRxiv, 2023

https://doi.org/10.1101/2023.06.01.543345

Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Kevin Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing

Nature Biotechnology, 2023

https://doi.org/10.1038/s41587-023-01679-x

Bowen Li, Rajith Singh Manan, Shun-Qing Liang, Akiva Gordon, Allen Jiang, Andrew Varley, Guangping Gao, Robert Langer, Wen Xue & Daniel Anderson

Clinical delivery of circular RNA: Lessons learned from RNA drug development

Advanced Drug Delivery Reviews, 2023

https://doi.org/10.1016/j.addr.2023.114826

Tiana Loan Young, Kevin Chang Wang, Andrew James Varley, Bowen Li

Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy

Angewandte Chemie International Edition, 2023

https://doi.org/10.1002/anie.202218218

Tiffany Ho, Keegan Guidolin, Ali Makky, Michael Valic, Lili Ding, Jiachuan Bu, Mark Zheng, Miffy HY Cheng, Jeremy Yau, Juan Chen, Gang Zheng

N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer

Gastroenterology, 2022

https://doi.org/10.1053/j.gastro.2021.12.269

Shiyan Wang, Shanshan Gao, Yong Zeng, Lin Zhu, Yulin Mo, Chi Chun Wong, Yi Bao, Peiran Su, Jianning Zhai, Lina Wang, Fraser Soares, Xin Xu, Huarong Chen, Kebria Hezaveh, Xinpei Ci, Aobo He, Tracy McGaha, Catherine O'Brien, Robert Rottapel, Wei Kang, Jianfeng Wu, Gang Zheng, Zongwei Cai, Jun Yu, Housheng Hansen He