Publications
Our publications cover a wide range of topics, from RNA structure and function to the development and testing of new RNA-based therapies.
Featured
Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation
Cancer Cell, 2025
Mona Teng, Jiacheng, Xin Xu, Xinpei Ci, Yulin Mo, Yakup Kohen, Zuyao Ni, Sujun Chen, Wang Yuan Guo, Martin Bakht, Shengyu Ku, Michael Sigouros, Wenqin Luo, Colette Maya Macarios, Ziting Xia, Moliang Chen, Sami Ul Haq, Wen Yang, Alejandro Berlin, Theo van der Kwast, Leigh Ellis, Amina Zoubeidi, Gang Zheng, Jie Ming, Yuzhuo Wang, Haissi Cui, Benjamin H. Lok, Brian Raught, Himisha Beltran, Jun Qin, and Housheng Hansen He
Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles
Journal of the American Chemical Society, 2025
Yulin Mo, Alexander F. A. Keszei, Shagun Kothari, Heyi Liu, Anni Pan, Paige Kim, Jiachuan Bu, Albert Kamanzi, David L. Dai, Mohammad T. Mazhab-Jafari, Juan Chen*, Sabrina Leslie and Gang Zheng*
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions
Nature Genetics, 2024
Peiran Su, Yin Liu, Tianyi Chen, Yibo Xue, Yong Zeng, Guanghui Zhu, Sujun Chen, Mona Teng, Xinpei Ci, Mengdi Guo, Michael Y. He, Jun Hao, Vivian Chu, Wenxi Xu, Shiyan Wang, Parinaz Mehdipour, Xin Xu, Sajid A. Marhon, Fraser Soares, Nhu-An Pham, Bell Xi Wu, Peter Hyunwuk Her, Shengrui Feng, Najd Alshamlan, Maryam Khalil, Rehna Krishnan, Fangyou Yu, Chang Chen, Francis Burrows, Razqallah Hakem, Mathieu Lupien, Shane Harding, Benjamin H. Lok, Catherine O’Brien, Alejandro Berlin, Daniel D. De Carvalho, David G. Brooks, Daniel Schramek, Ming-Sound Tsao & Housheng Hansen He
Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry
Nature Materials, 2024
Bowen Li, Idris O. Raji, Akiva G. R. Gordon, Lizhuang Sun, Theresa M. Raimondo, Favour A. Oladimeji, Allen Y. Jiang, Andrew Varley, Robert S. Langer & Daniel G. Anderson
Tumor-Tailored Ionizable Lipid Nanoparticles Facilitate IL-12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy
Advanced Materials, 2024
Nature Biomedical Engineering, 2023
Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M. Raimondo, Akiva G. R. Gordon, Luke H. Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, Haseeb Mughal, Taras M. Chicz, Yue Xu, Ryan P. McNamara, Sangeeta Bhatia, Galit Alter, Robert Langer & Daniel G. Anderson
Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
PNAS, 2023
Jingan Chen, Yue Xu, Muye Zhou and Bowen Li
Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles
ACS Nano, 2023
Yulin Mo, Miffy HY Cheng, Andrew D’Elia, Katie Doran, Lili Ding, Juan Chen, Pieter R Cullis, Gang Zheng
Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
J. Mater. Chem. B, 2023
Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, and Bowen Li
AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery
bioRxiv, 2023
Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Kevin Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li
Nature Biotechnology, 2023
Bowen Li, Rajith Singh Manan, Shun-Qing Liang, Akiva Gordon, Allen Jiang, Andrew Varley, Guangping Gao, Robert Langer, Wen Xue & Daniel Anderson
Clinical delivery of circular RNA: Lessons learned from RNA drug development
Advanced Drug Delivery Reviews, 2023
Angewandte Chemie International Edition, 2023
Tiffany Ho, Keegan Guidolin, Ali Makky, Michael Valic, Lili Ding, Jiachuan Bu, Mark Zheng, Miffy HY Cheng, Jeremy Yau, Juan Chen, Gang Zheng
Gastroenterology, 2022
Shiyan Wang, Shanshan Gao, Yong Zeng, Lin Zhu, Yulin Mo, Chi Chun Wong, Yi Bao, Peiran Su, Jianning Zhai, Lina Wang, Fraser Soares, Xin Xu, Huarong Chen, Kebria Hezaveh, Xinpei Ci, Aobo He, Tracy McGaha, Catherine O'Brien, Robert Rottapel, Wei Kang, Jianfeng Wu, Gang Zheng, Zongwei Cai, Jun Yu, Housheng Hansen He